Todd is a bioinformatics analyst and molecular biology researcher in the Research Informatics (RI) Bioinformatics division of MSI. He supports research projects and custom clinical genomics pipelines for the Department of Laboratory Medicine and Pathology (LMP) and the Molecular Diagnostics Laboratory (MDL). He has experience analyzing high-throughput datasets for gene expression analysis, microbial detection and genome assembly, and variant detection. Todd's graduate training focused on the genetic mechanisms of breast cancer, where he investigated how activated growth factor signaling pathways regulate post-translational modifications of the progesterone receptor, causing altered gene expression programming and tumor progression. As a postdoc in the UMN Veterinary Diagnostic Laboratory, he transitioned to microbial genomics, where he developed pipelines for analyzing metagenomic shotgun sequencing data for the discovery of novel viral and bacterial pathogens. At MSI, he enjoys working with new collaborators and facilitating computational biology projects.
- Gene expression profiling (RNA-seq, microarray, NanoString)
- Single-cell gene expression profiling
- Differential gene expression and pathway analysis
- Prognostic gene signatures in breast cancer
- Metagenomics for viral detection, assembly, and phylogenetics
- Bacterial genome assembly and resistance gene identification
- SNP/indel variant calling (DNA-seq)
- Reproducible research
- Grant-writing support
- MS, Bioinformatics and Computational Biology, University of Minnesota, Minneapolis, Minnesota
- Postdoc, Veterinary Diagnostic Laboratory, University of Minnesota, St. Paul, Minnesota
- Postdoc, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota
- PhD, Molecular, Cellular, Developmental Biology, and Genetics, University of Minnesota, Minneapolis, Minnesota
- BS, Genetics, Cell Biology, and Development & Neuroscience, University of Minnesota, Minneapolis, Minnesota