Professor Kris Hogquist

T lymphocytes acquire their essential characteristics during development in the thymus.  These properties - clonal expression of antigen receptors, major histocompatibility complex (MHC) restriction, self-tolerance, and lineage specific effector function - are continually established in the thymus as progenitors develop throughout the life of the animal. These researchers study how MHC restriction and self-tolerance are imprinted using genetically engineered mouse models. Current approaches include flow cytometry, RNA-seq, 10x Genomics scRNA-seq, and fluorescent imaging.

This research was featured on the MSI website in October 2014: Genetic Studies of Epstein-Barr Virus Infection.